Variation in 100 relevant pharmacogenes among emiratis with insights from understudied populations.

ABSTRACT: Genetic variations have an established impact on the pharmacological response. Investigating this variation resulted in a compilation of variants in "pharmacogenes". The emergence of next-generation sequencing facilitated large-scale pharmacogenomic studies and exhibited the extensive variability of pharmacogenes. Some rare and population-specific variants proved to be actionable, suggesting the significance of population pharmacogenomic research. A profound gap exists in the knowledge of pharmacogenomic variants enriched in some populations, including the United Arab Emirates (UAE). The current study aims to explore the landscape of variations in relevant pharmacogenes among healthy Emiratis. Through the resequencing of 100 pharmacogenes for 100 healthy Emiratis, we identified 1243 varian

SUBMITTER: Al-Mahayri ZN 

PROVIDER: S-EPMC7718919 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature