Recent progress in translational engineered in vitro models of the central nervous system.

ABSTRACT: The complexity of the human brain poses a substantial challenge for the development of models of the CNS. Current animal models lack many essential human characteristics (in addition to raising operational challenges and ethical concerns), and conventional in vitro models, in turn, are limited in their capacity to provide information regarding many functional and systemic responses. Indeed, these challenges may underlie the notoriously low success rates of CNS drug development efforts. During the past 5 years, there has been a leap in the complexity and functionality of in vitro systems of the CNS, which have the potential to overcome many of the limitations of traditional model systems. The availability of human-derived induced pluripotent stem cell technology has further increased the tr

SUBMITTER: Nikolakopoulou P 

PROVIDER: S-EPMC7719033 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature