Epithelial-mesenchymal transition polarization in ovarian carcinomas from patients with high social isolation.

ABSTRACT:

Background

Social isolation has shown robust associations with clinical outcomes in the general population and in patients with cancer. In patients with ovarian cancer, social isolation has been found to be related to decreased survival and multiple biomarkers supporting tumor progression. However, to the authors' knowledge, little is known regarding the relationship between social isolation and the molecular characteristics of ovarian tumors. Herein, the authors have used genome-wide transcriptional profiling to quantify associations between social isolation and epithelial-mesenchymal transition (EMT) polarization in ovarian tumors and transcriptome-driven, promoter-based bioinformatics analyses to identify gene regulatory pathways that may potentially underlie these changes.

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SUBMITTER: Lutgendorf SK 

PROVIDER: S-EPMC7719066 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature