A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding.

ABSTRACT: Marked deficits in glucose availability, or glucoprivation, elicit organism-wide counter-regulatory responses whose purpose is to restore glucose homeostasis. However, while catecholamine neurons of the ventrolateral medulla (VLM^CA) are thought to orchestrate these responses, the circuit and cellular mechanisms underlying specific counter-regulatory responses are largely unknown. Here, we combined anatomical, imaging, optogenetic and behavioral approaches to interrogate the circuit mechanisms by which VLM^CA neurons orchestrate glucoprivation-induced food seeking behavior. Using these approaches, we found that VLM^CA neurons form functional connections with nucleus accumbens (NAc)-projecting neurons of the posterior portion of the paraventricular nucleus of t

SUBMITTER: Sofia Beas B 

PROVIDER: S-EPMC7719163 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature