Simultaneous Pharmacokinetic Analysis of Nitrate and its Reduced Metabolite, Nitrite, Following Ingestion of Inorganic Nitrate in a Mixed Patient Population.

ABSTRACT:

Purpose

The pharmacokinetic properties of plasma NO₃^- and its reduced metabolite, NO₂^-, have been separately described, but there has been no reported attempt to simultaneously model their pharmacokinetics following NO₃^- ingestion. This report describes development of such a model from retrospective analyses of concentrations largely obtained from primary endpoint efficacy trials.

Methods

Linear and non-linear mixed effects analyses were used to statistically define concentration dependency on time, dose, as well as patient and study variables, and to integrate NO₃^- and NO₂^- concentrations from studies conducted at different times, locations, patient groups, and seve

SUBMITTER: Coggan AR 

PROVIDER: S-EPMC7719268 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature