Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis.

ABSTRACT:

Background

Breast cancer is the leading cause of cancer-related deaths in women, demanding new treatment options. With the advent of immune checkpoint blockade, immunotherapy emerged as a treatment option. In addition to lymphocytes, tumor-associated macrophages exert a significant, albeit controversial, impact on tumor development. Pro-inflammatory macrophages are thought to hinder, whereas anti-inflammatory macrophages promote tumor growth. However, molecular markers to identify prognostic macrophage populations remain elusive.

Methods

We isolated two macrophage subsets, from 48 primary human breast tumors, distinguished by the expression of CD206. Their transcriptomes were analyzed via RNA-Seq, and potential prognostic macrophage markers were validated by PhenOptics in ti

SUBMITTER: Strack E 

PROVIDER: S-EPMC7719284 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature