Persistence of Antipsychotic Use After Clozapine Discontinuation: A Real-World Study Across Antipsychotics.

ABSTRACT: Although clozapine treatment is often discontinued due to limited efficacy or low tolerability, there is a lack of guidelines and evidence on treatment options after discontinuation of clozapine in patients with schizophrenia. Persistence has proven to be an adequate indicator for treatment effectiveness in patients with schizophrenia. The aim of this study was, therefore, to compare persistence of antipsychotic use between antipsychotic treatment options in patients after stopping clozapine treatment. Registry data from a prescription database representative of the Dutch population (1996-2017) was collected to investigate persistence in patients with schizophrenia who had been using clozapine for ≥ 90 days. Persistence with antipsychotics after clozapine discontinuation was analyzed using

SUBMITTER: Stam N 

PROVIDER: S-EPMC7719358 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature