Serum Metabolomic Profiles Associated With Untreated Metabolic Syndrome Patients in the Chinese Population.

ABSTRACT: Metabolomics is a promising technology for elucidating the mechanisms of metabolic syndrome (MetS). However, measurements in patients with MetS under different conditions vary. Metabolomics experiments in different populations and pathophysiological conditions are, therefore, indispensable. We performed a serum metabolomics investigation in untreated patients with MetS in the Chinese population. Untreated patients with MetS were recruited to this study. Metabolites were measured using a traditional ¹ H nuclear magnetic resonance (NMR) experiment followed by principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Key metabolic pathways were identified by searching the Kyoto Encyclopedia of Genes and Genomes Pathway Database. A tota

SUBMITTER: Li Y 

PROVIDER: S-EPMC7719370 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature