Identification of Critical Windows of Metabolic Programming of Metabolism and Lung Function in Male Offspring of Obese Dams.

ABSTRACT: Perinatal nutritional determinants known as metabolic programming could be either detrimental or protective. Maternal obesity in the perinatal period determines susceptibility for diseases, such as obesity, metabolic disorders, and lung disease. Although this adverse metabolic programming is well-recognized, the critical developmental window for susceptibility risk remains elusive. Thus, we aimed to define the vulnerable window for impaired lung function after maternal obesity; and to test if dietary intervention protects. First, we studied the impact of high-fat diet (HFD)-induced maternal obesity during intrauterine (HFD^iu ), postnatal (HFD^post ), or perinatal (i.e., intrauterine and postnatal (HFD^peri ) phase on body weight, white adipose tissue (WAT), g

SUBMITTER: Dinger K 

PROVIDER: S-EPMC7719392 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature