A variable resolution approach for improved acquisition of hyperpolarized ¹³ C metabolic MRI.

ABSTRACT:

Purpose

To ameliorate tradeoffs between a fixed spatial resolution and signal-to-noise ratio (SNR) for hyperpolarized ¹³ C MRI.

Methods

In MRI, SNR is proportional to voxel volume but retrospective downsampling or voxel averaging only improves SNR by the square root of voxel size. This can be exploited with a metabolite-selective imaging approach that independently encodes each compound, yielding high-resolution images for the injected substrate and coarser resolution images for downstream metabolites, while maintaining adequate SNR for each. To assess the efficacy of this approach, hyperpolarized [1-¹³ C]pyruvate data were acquired in healthy Sprague-Dawley rats (n = 4) and in two healthy human subjects.

Results

Compared with a constant resoluti

SUBMITTER: Gordon JW 

PROVIDER: S-EPMC7719570 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature