Obstructive Sleep Apnea and Risk for Incident Vertebral and Hip Fracture in Women.

ABSTRACT: Recent studies suggest a positive association between obstructive sleep apnea (OSA), a disorder associated with intermittent hypoxia and sleep fragmentation, and derangements in bone metabolism. However, no prospective study to date has investigated the association between OSA and fracture risk in women. We conducted a prospective study examining the relation between OSA and risk of incident vertebral fracture (VF) and hip fracture (HF) in the Nurses' Health Study. History of physician-diagnosed OSA was assessed by self-reported questionnaires. A previous validation study demonstrated high concordance between self-reports and medical record identification of OSA. OSA severity was further categorized according to the presence or absence of self-reported sleepiness. Self-reports of VF were c

SUBMITTER: Huang T 

PROVIDER: S-EPMC7719618 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature