Biomarkers for Heart Failure Prognosis: Proteins, Genetic Scores and Non-coding RNAs.

ABSTRACT: Heart failure (HF) is a complex disease in which cardiomyocyte injury leads to a cascade of inflammatory and fibrosis pathway activation, thereby causing decrease in cardiac function. As a result, several biomolecules are released which can be identified easily in circulating body fluids. The complex biological processes involved in the development and worsening of HF require an early treatment strategy to stop deterioration of cardiac function. Circulating biomarkers provide not only an ideal platform to detect subclinical changes, their clinical application also offers the opportunity to monitor disease treatment. Many of these biomarkers can be quantified with high sensitivity; allowing their clinical application to be evaluated beyond diagnostic purposes as potential tools for HF progn

SUBMITTER: Shrivastava A 

PROVIDER: S-EPMC7719677 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature