Reduced Interhemispheric Coherence in Cerebellar Kainic Acid-Induced Lateralized Dystonia.

ABSTRACT: The execution of voluntary muscular activity is controlled by the primary motor cortex, together with the cerebellum and basal ganglia. The synchronization of neural activity in the intracortical network is crucial for the regulation of movements. In certain motor diseases, such as dystonia, this synchrony can be altered in any node of the cerebello-cortical network. Questions remain about how the cerebellum influences the motor cortex and interhemispheric communication. This research aims to study the interhemispheric cortical communication between the motor cortices during dystonia, a neurological movement syndrome consisting of sustained or repetitive involuntary muscle contractions. We pharmacologically induced lateralized dystonia to adult male albino mice by administering low doses o

SUBMITTER: Georgescu Margarint EL 

PROVIDER: S-EPMC7719699 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature