Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics.

ABSTRACT: Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 10¹¹ cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, which proliferate and mature into erythrocytes. During erythropoiesis, mitochondria are reprogrammed to drive the differentiation process before finally being eliminated by mitophagy. In erythropoiesis, mitochondrial dynamics (MtDy) are expected to be a key regulatory point that has not been described previously. We described that a specific MtDy pattern occurs in human erythropoiesis from EPO-induced human CD34⁺ cells, characterized predominantly by mitochondrial fusion at early stages followed by fission at late stages. The fusion protein MFN1

SUBMITTER: Gonzalez-Ibanez AM 

PROVIDER: S-EPMC7719720 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature