Endotoxemia and circulating bacteriome in severe COVID-19 patients.

ABSTRACT:

Background

When severe, COVID-19 shares many clinical features with bacterial sepsis. Yet, secondary bacterial infection is uncommon. However, as epithelium is injured and barrier function is lost, bacterial products entering the circulation might contribute to the pathophysiology of COVID-19.

Methods

We studied 19 adults, severely ill patients with COVID-19 infection, who were admitted to King Chulalongkorn Memorial Hospital, Bangkok, Thailand, between 13th March and 17th April 2020. Blood samples on days 1, 3, and 7 of enrollment were analyzed for endotoxin activity assay (EAA), (1 → 3)-β-D-glucan (BG), and 16S rRNA gene sequencing to determine the circulating bacteriome.

Results

Of the 19 patients, 13 were in intensive care and 10 patients received mechanical venti

SUBMITTER: Sirivongrangson P 

PROVIDER: S-EPMC7719737 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature