Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways.

ABSTRACT: For several decades there has been accumulating evidence implicating type I interferons (IFNs) as key elements of the immune response. Therapeutic approaches incorporating different recombinant type I IFN proteins have been successfully employed to treat a diverse group of diseases with significant and positive outcomes. The biological activities of type I IFNs are consequences of signaling events occurring in the cytoplasm and nucleus of cells. Biochemical events involving JAK/STAT proteins that control transcriptional activation of IFN-stimulated genes (ISGs) were the first to be identified and are referred to as "canonical" signaling. Subsequent identification of JAK/STAT-independent signaling pathways, critical for ISG transcription and/or mRNA translation, are denoted as "non-canonica

SUBMITTER: Mazewski C 

PROVIDER: S-EPMC7719805 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature