Accurate assembly of the olive baboon (Papio anubis) genome using long-read and Hi-C data.

ABSTRACT:

Background

Baboons are a widely used nonhuman primate model for biomedical, evolutionary, and basic genetics research. Despite this importance, the genomic resources for baboons are limited. In particular, the current baboon reference genome Panu_3.0 is a highly fragmented, reference-guided (i.e., not fully de novo) assembly, and its poor quality inhibits our ability to conduct downstream genomic analyses.

Findings

Here we present a de novo genome assembly of the olive baboon (Papio anubis) that uses data from several recently developed single-molecule technologies. Our assembly, Panubis1.0, has an N50 contig size of ∼1.46 Mb (as opposed to 139 kb for Panu_3.0) and has single scaffolds that span each of the 20 autosomes and the X chromosome.

Conclusions

We highlight m

SUBMITTER: Batra SS 

PROVIDER: S-EPMC7719865 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature