Corticosteroid treatment for early acute respiratory distress syndrome: a systematic review and meta-analysis of randomized trials.

ABSTRACT:

Background

The effect of corticosteroid treatment on survival outcome in early acute respiratory distress syndrome (ARDS) is still debated. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the efficacy of prolonged corticosteroid therapy in early ARDS.

Methods

We assessed the MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science databases from inception to August 1, 2020. We included RCTs that compared prolonged corticosteroid therapy with control treatment wherein the intervention was started within 72 h of ARDS diagnosis. Two investigators independently screened the citations and conducted the data extraction. The primary outcomes were all-cause 28- or 30-day mortality and 60-day mortality. Several en

SUBMITTER: Hirano Y 

PROVIDER: S-EPMC7720037 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature