Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is heterogeneous and may be amenable to sub-phenotyping to improve enrichment for trials. We aimed to identify subtypes of pediatric ARDS based on whole blood transcriptomics.

Methods

This was a prospective observational study of children with ARDS at the Children's Hospital of Philadelphia (CHOP) between January 2018 and June 2019. We collected blood within 24 h of ARDS onset, generated expression profiles, and performed k-means clustering to identify sub-phenotypes. We tested the association between sub-phenotypes and PICU mortality and ventilator-free days at 28 days using multivariable logistic and competing risk regression, respectively.

Results

We enrolled 106 subjects, of whom 96 had usable samples. We ident

SUBMITTER: Yehya N 

PROVIDER: S-EPMC7720038 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature