Hub gene identification and prognostic model construction for isocitrate dehydrogenase mutation in glioma.

ABSTRACT: Our study attempted to identify hub genes related to isocitrate dehydrogenase (IDH) mutation in glioma and develop a prognostic model for IDH-mutant glioma patients. In a first step, ten hub genes significantly associated with the IDH status were identified by weighted gene coexpression analysis (WGCNA). The functional enrichment analysis demonstrated that the most enriched terms of these hub genes were cadherin binding and glutathione metabolism. Three of these hub genes were significantly linked with the survival of glioma patients. 328 samples of IDH-mutant glioma were separated into two datasets: a training set (N = 228) and a test set (N = 100). Based on the training set, we identified two IDH-mutant subtypes with significantly different pathological features by using consensus cluste

SUBMITTER: Jia Y 

PROVIDER: S-EPMC7720094 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature