Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells.

ABSTRACT: IL-17-producing Th17 cells are implicated in the pathogenesis of rheumatoid arthritis (RA) and TNF-α, a proinflammatory cytokine in the rheumatoid joint, facilitates Th17 differentiation. Anti-TNF therapy ameliorates disease in many patients with rheumatoid arthritis (RA). However, a significant proportion of patients do not respond to this therapy. The impact of anti-TNF therapy on Th17 responses in RA is not well understood. We conducted high-throughput gene expression analysis of Th17-enriched CCR6⁺CXCR3^-CD45RA^- CD4⁺ T (CCR6⁺ T) cells isolated from anti-TNF-treated RA patients classified as responders or nonresponders to therapy. CCR6⁺ T cells from responders and nonresponders had distinct gene expression profiles. Proinf

SUBMITTER: Hu D 

PROVIDER: S-EPMC7720234 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature