Long-term effects of PM_2·5 on neurological disorders in the American Medicare population: a longitudinal cohort study.

ABSTRACT:

Background

Accumulating evidence links fine particulate matter (PM_2·5) to premature mortality, cardiovascular disease, and respiratory disease. However, less is known about the influence of PM_2·5 on neurological disorders. We aimed to investigate the effect of long-term PM_2·5 exposure on development of Parkinson's disease or Alzheimer's disease and related dementias.

Methods

We did a longitudinal cohort study in which we constructed a population-based nationwide open cohort including all fee-for-service Medicare beneficiaries (aged ≥65 years) in the contiguous United States (2000-16) with no exclusions. We assigned PM_2·5 postal code (ie, ZIP code) concentrations based on mean annual predictions from a high-resolution model. To acco

SUBMITTER: Shi L 

PROVIDER: S-EPMC7720425 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature