Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis.

ABSTRACT:

Background

The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy is essential for sorafenib resistance, and the mitophagy core regulator gene ATAD3A (ATPase family AAA domain containing 3A) was down regulated in hypoxia induced resistant HCC cells. Blocking mitophagy may restore the sorafenib sensitivity of these cells and provide a new treatment strategy for HCC patients.

Methods

Hypoxia induced sorafenib resistant cancer cells were established by culturing under 1% O₂ with increasing drug treatment. RNA sequencing was conducted in

SUBMITTER: Wu H 

PROVIDER: S-EPMC7720487 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature