Bioinformatic analysis and functional predictions of selected regeneration-associated transcripts expressed by zebrafish microglia.

ABSTRACT:

Background

Unlike mammals, zebrafish have a remarkable capacity to regenerate a variety of tissues, including central nervous system tissue. The function of macrophages in tissue regeneration is of great interest, as macrophages respond and participate in the landscape of events that occur following tissue injury in all vertebrate species examined. Understanding macrophage populations in regenerating tissue (such as in zebrafish) may inform strategies that aim to regenerate tissue in humans. We recently published an RNA-seq experiment that identified genes enriched in microglia/macrophages in regenerating zebrafish retinas. Interestingly, a small number of transcripts differentially expressed by retinal microglia/macrophages during retinal regeneration did not have predicted orthol

SUBMITTER: Issaka Salia O 

PROVIDER: S-EPMC7720500 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature