Development and validation of a VHL-associated immune prognostic signature for clear cell renal cell carcinoma.

ABSTRACT:

Background

VHL mutation is the most common mutation in clear cell renal cell carcinoma (ccRCC). Here, we developed and validated an immune-related signature to predict the prognosis of ccRCC with VHL mutations.

Methods

VHL mutation status and RNA expression were analysed in the TCGA datasets and our cohort. LASSO Cox analysis was performed to develop an immune-related signature. Candidate genes for the immune-related signature were differentially expressed between VHLwt and VHLmut ccRCC patients.

Results

VHL mutations resulted in the downregulation of the immune response in ccRCC. To develop an immune-related signature, LASSO Cox analysis was constructed by immune-related genes that were differentially expressed between VHLwt (WHL wild type) and VHLmut (VHL mutation)

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7720505 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature