Rapid detection of SARS-CoV-2-specific memory T-cell immunity in recovered COVID-19 cases.

ABSTRACT:

Objectives

There is emerging evidence that SARS-CoV-2-specific memory T-cell responses are likely to provide critical long-term protection against COVID-19. Strategies to rapidly assess T-cell responses are therefore likely to be important for assessing immunity in the global population.

Methods

Here, we have developed a rapid immune-monitoring strategy to assess virus-specific memory T-cell responses in the peripheral blood of COVID-19 convalescent individuals. We validated SARS-CoV-2-specific memory T-cell responses detected in whole blood using in vitro expansion with SARS-CoV-2 proteins.

Results

T-cell immunity characterised by the production of IFN-γ and IL-2 could be consistently detected in the whole blood of recovered participants. T cells predominantly

SUBMITTER: Lineburg KE 

PROVIDER: S-EPMC7720530 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature