DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter.

ABSTRACT:

Background

The IGF2 (insulin-like growth factor 2) and H19 gene cluster plays an important role during pregnancy as it promotes both foetal and placental growth. We investigated the association between cord blood DNA methylation status of the IGF2/H19 gene cluster and maternal fine particulate matter exposure during fetal life. To the best of our knowledge, this is the first study investigating the association between prenatal PM_2.5 exposure and newborn DNA methylation of the IGF2/H19.

Methods

Cord blood DNA methylation status of IGF2/H19 cluster was measured in 189 mother-newborn pairs from the ENVIRONAGE birth cohort (Flanders, Belgium). We assessed the sex-specific association between residential PM_2.5 exposure during pregnancy and the methylation le

SUBMITTER: Wang C 

PROVIDER: S-EPMC7720562 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature