Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study.

ABSTRACT:

Objectives

To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS).

Methods

Seventy-two MwoA patients and forty-six HS were recruited. 3D-T1 and resting state fMRI data were collected during the interictal period for MwoA and HS. Voxel-based morphometry (VBM) for structure analysis and regional homogeneity (Reho) for fMRI analysis were applied. The VBM and Reho maps were overlapped to determine a possible brain region with concurrent functional and structural alteration in MwoA patients. Further analysis of resting state functional connectivity (FC) alteration was applied with this brain region as the seed.

Results

Compared with HS, MwoA patients showed decr

SUBMITTER: Li Z 

PROVIDER: S-EPMC7720576 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature