The haplotypes of various TNF related genes associated with scleritis in Chinese Han.

ABSTRACT:

Background

Several studies have stated that TNF-α participates in the pathogenesis of scleritis, but also in several systemic autoimmune diseases and vasculitis, of which some are associated with scleritis. Earlier GWAS and SNP studies have confirmed that multiple SNPs of TNF related genes are associated with many immune-mediated disorders. The purpose of this study was to examine the association of TNF related gene polymorphisms with scleritis in Chinese Han. A case-control study was carried out in 556 non-infectious scleritis cases and 742 normal controls. A total of 28 single-nucleotide polymorphisms (SNPs) were genotyped by the iPLEXGold genotyping assay.

Results

No significant correlations were seen between the individual SNPs in the TNF related genes and scleritis. Hap

SUBMITTER: Gao Y 

PROVIDER: S-EPMC7720609 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature