Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs.

ABSTRACT:

Background

As core units of organ tissues, cells of various types play their harmonious rhythms to maintain the homeostasis of the human body. It is essential to identify the characteristics of cells in human organs and their regulatory networks for understanding the biological mechanisms related to health and disease. However, a systematic and comprehensive single-cell transcriptional profile across multiple organs of a normal human adult is missing.

Results

We perform single-cell transcriptomes of 84,363 cells derived from 15 tissue organs of one adult donor and generate an adult human cell atlas. The adult human cell atlas depicts 252 subtypes of cells, including major cell types such as T, B, myeloid, epithelial, and stromal cells, as well as novel COCH⁺ fibro

SUBMITTER: He S 

PROVIDER: S-EPMC7720616 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature