Effect of liver fibrosis on survival in patients with intrahepatic cholangiocarcinoma: a SEER population-based study.

ABSTRACT:

Background

Intrahepatic cholangiocarcinoma (iCCA) is a biliary tract malignancy with rising incidence in recent decades. While the causative role of cirrhosis in the development of iCCA is well established, the role of cirrhosis as a prognostic factor in iCCA is debatable.

Materials and methods

The study population consisted of 512 patients diagnosed with iCCA between 2004-2016 collected from the Surveillance, Epidemiology and End Results (SEER) database. The impact of fibrosis on overall and cancer-specific survival 12, 36 and 60 months following diagnosis, was evaluated in the entire cohort and in sub-groups stratified according to treatment approach and the American Joint Committee on Cancer (AJCC) tumor stage using a Cox proportional-hazards model.

Results

After a

SUBMITTER: Levy NA 

PROVIDER: S-EPMC7720776 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature