A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease.

ABSTRACT:

Introduction

The progression rate of Alzheimer's disease (AD) varies and might be affected by the triggering receptor expressed on myeloid cells (TREM2) activity. We explored if cerebrospinal fluid (CSF) soluble TREM2 (sTREM2), a proxy of microglial activity, is associated with clinical progression rate.

Methods

Patients with clinical AD (N = 231) were followed for up to 3 years after diagnosis. Cognitively healthy controls (N = 42) were followed for 5 years. CSF sTREM2 was analyzed by enzyme-linked immunosorbent assay. Group-based trajectory modeling revealed distinct clinical progression groups.

Results

Higher CSF sTREM2 was associated with slow clinical progression. The slow- and medium-progressing groups had higher CSF sTREM2 than the cognitively healthy, who had

SUBMITTER: Edwin TH 

PROVIDER: S-EPMC7720866 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature