Activation of the Sympathetic Nervous System Promotes Blood Pressure Salt-Sensitivity in C57BL6/J Mice.

ABSTRACT: Global salt intake averages >8 g/person per day, over twice the limit advocated by the American Heart Association. Dietary salt excess leads to hypertension, and this partly mediates its poor health outcomes. In ≈30% of people, the hypertensive response to salt is exaggerated. This salt-sensitivity increases cardiovascular risk. Mechanistic cardiovascular research relies heavily on rodent models and the C57BL6/J mouse is the most widely used reference strain. We examined the effects of high salt intake on blood pressure, renal, and vascular function in the most commonly used and commercially available C57BL6/J mouse strain. Changing from control (0.3% Na⁺) to high salt (3% Na⁺) diet increased systolic blood pressure in male mice by ≈10 mm Hg within 4 days of dietary s

SUBMITTER: Ralph AF 

PROVIDER: S-EPMC7720873 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature