Endotoxemia coupled with heightened inflammation predicts future depressive symptoms.

ABSTRACT:

Objective

Cross-sectional data have linked gut barrier abnormalities and endotoxemia with depression, even among those without gastrointestinal symptoms. This study examined longitudinal associations between endotoxemia markers and depressive symptoms, as well as the role of inflammation in this relationship.

Design

At three annual visits, 315 women (n=209 breast cancer survivors, n = 106 non-cancer patient controls, M=55 years old) completed the Center for Epidemiological Studies Depression questionnaire (CES-D) and provided blood samples to assess inflammatory markers - interleukin-6, tumor necrosis factor-alpha, and C-reactive protein - and endotoxemia markers - lipopolysaccharide-binding protein (LBP), soluble CD14 (sCD14), and their ratio.

Results

Adjusting for k

SUBMITTER: Madison AA 

PROVIDER: S-EPMC7721058 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature