The m6A methylation landscape stratifies hepatocellular carcinoma into 3 subtypes with distinct metabolic characteristics.

ABSTRACT:

Objective

Epigenetic aberration plays an important role in the development and progression of hepatocellular carcinoma (HCC). However, the alteration of RNA N6-methyladenosine (m6A) modifications and its role in HCC progression remain unclear. We therefore aimed to provide evidence using bioinformatics analysis.

Methods

We comprehensively analyzed the m6A regulator modification patterns of 605 HCC samples and correlated them with metabolic alteration characteristics. We elucidated 390 gene-based m6A-related signatures and defined an m6Ascore to quantify m6A modifications. We then assessed their values for predicting prognoses and therapeutic responses in HCC patients.

Results

We identified 3 distinct m6A modification patterns in HCC, and each pattern had distinct meta

SUBMITTER: Shen X 

PROVIDER: S-EPMC7721089 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature