Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2.

ABSTRACT:

Motivation

Beside socio-economic issues, coronavirus pandemic COVID-19, the infectious disease caused by the newly discovered coronavirus SARS-CoV-2, has caused a deep impact in the scientific community, that has considerably increased its effort to discover the infection strategies of the new virus. Among the extensive and crucial research that has been carried out in the last months, the analysis of the virus-host relationship plays an important role in drug discovery. Virus-host protein-protein interactions are the active agents in virus replication, and the analysis of virus-host protein-protein interaction networks is fundamental to the study of the virus-host relationship.

Results

We have adapted and implemented a recent integer linear programming model for protein-pro

SUBMITTER: Llabres M 

PROVIDER: S-EPMC7721128 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature