Neutrophil-to-lymphocyte ratio predicts early mortality in females with metastatic triple-negative breast cancer.

ABSTRACT:

Background

The aim of this study was to determine the utility of the neutrophil-to-lymphocyte ratio (NLR) as a biomarker for predicting early-mortality (<2 years) among females with metastatic triple-negative breast cancer (mTNBC).

Methods

We reviewed 118 medical records of females with mTNBC. The cut-off value for the NLR (<2.5 and ≥2.5) was determined with receiver operating characteristic curves (area under the curve: 0.73; 95% CI: 0.62-0.85). Survival curves were estimated using the Kaplan-Meier method and compared with the Log-rank test. Multivariate Cox regression was used to identify the risk of mortality at two years. Moreover, we performed sensitivity analyses with different cut-off values and a subgroup analysis in females that only received chemotherapy.

Result

SUBMITTER: de la Cruz-Ku G 

PROVIDER: S-EPMC7721150 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature