Human Milk Oligosaccharides Support Normal Bowel Function and Improve Symptoms of Irritable Bowel Syndrome: A Multicenter, Open-Label Trial.

ABSTRACT:

Introduction

Treatment options for irritable bowel syndrome (IBS) are limited, causing many patients to remain symptomatic. This study assessed the potential of human milk oligosaccharides (HMOs) to normalize bowel habits. Secondary outcomes included IBS severity and health-related quality of life.

Methods

This multicenter, open-label trial recruited patients with IBS from 17 sites across the United States. Patients received daily orally administrated 5-g intervention of the HMOs 2'-fucosyllactose and lacto-N-neotetraose in a 4:1 mix. Bowel habits, IBS symptoms, and quality of life were assessed at baseline and every 4 weeks during the 12-week intervention.

Results

A total of 317 patients (70.7% women; mean age of 44.0 years, range 18-93 years) received the trial prod

SUBMITTER: Palsson OS 

PROVIDER: S-EPMC7721220 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature