IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection.

ABSTRACT: Development of tissue-resident memory (T_RM) CD8 T cells depends on CD4 T cells. In polyomavirus central nervous system infection, brain CXCR5^hi PD-1^hi CD4 T cells produce interleukin-21 (IL-21), and CD8 T cells lacking IL-21 receptors (IL21R^-/-) fail to become bT_RM IL-21⁺ CD4 T cells exhibit elevated T cell receptor (TCR) affinity and higher TCR density. IL21R^-/- brain CD8 T cells do not express CD103, depend on vascular CD8 T cells for maintenance, are antigen recall defective, and lack T_RM core signature genes. CD4 T cell-deficient and IL21R^-/- brain CD8 T cells show similar deficiencies in expression of genes for oxidative metabolism, and intrathecal delivery of IL-21 to CD4 T cell-deplete

SUBMITTER: Ren HM 

PROVIDER: S-EPMC7721466 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature