RNA sequencing analyses reveal differentially expressed genes and pathways as Notch2 targets in B-cell lymphoma.

ABSTRACT: Splenic marginal zone lymphoma (SMZL) is a low grade, indolent B-cell neoplasm that comprises approximately 10% of all lymphoma. Notch2, a pivotal gene for marginal zone differentiation is found to be mutated in SMZL. Deregulated Notch2 signaling has been involved in tumorigenesis and also in B-cell malignancies. However the role of Notch2 and the downstream pathways that it influences for development of B-cell lymphoma remains unclear. In recent years, RNA sequencing (RNA-Seq) has become a functional and convincing technology for profiling gene expression and to discover new genes and transcripts that are involved in disease development in a single experiment. In the present study, using transcriptome sequencing approach, we have identified key genes and pathways that are probably the und

SUBMITTER: Arasu A 

PROVIDER: S-EPMC7721612 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature