Definition of a genetic relatedness cutoff to exclude recent transmission of meticillin-resistant <i>Staphylococcus aureus</i>: a genomic epidemiology analysis.

ABSTRACT:

Background

Whole-genome sequencing (WGS) can be used in genomic epidemiology investigations to confirm or refute outbreaks of bacterial pathogens, and to support targeted and efficient infection control interventions. We aimed to define a genetic relatedness cutoff, quantified as a number of single-nucleotide polymorphisms (SNP), for meticillin-resistant Staphylococcus aureus (MRSA), above which recent (ie, within 6 months) patient-to-patient transmission could be ruled out.

Methods

We did a retrospective genomic and epidemiological analysis of MRSA data from two prospective observational cohort studies in the UK to establish SNP cutoffs for genetic relatedness, above which recent transmission was unlikely. We used three separate approaches to calculate these threshol

SUBMITTER: Coll F 

PROVIDER: S-EPMC7721685 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature