The H_abc domain of syntaxin 3 is a ubiquitin binding domain.

ABSTRACT: Syntaxins are a family of membrane-anchored SNARE proteins that are essential components required for membrane fusion in eukaryotic intracellular membrane trafficking pathways. Syntaxins contain an N-terminal regulatory domain, termed the H_abc domain that is not highly conserved at the primary sequence level but folds into a three-helix bundle that is structurally conserved among family members. The syntaxin H_abc domain has previously been found to be structurally very similar to the GAT domain present in GGA family members and related proteins that are otherwise completely unrelated to syntaxins. Because the GAT domain has been found to be a ubiquitin binding domain we hypothesized that the H_abc domain of syntaxins may also bind to ubiquitin. Here, we repo

SUBMITTER: Giovannone AJ 

PROVIDER: S-EPMC7721868 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature