Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity.

ABSTRACT: The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (PET) imaging with the 5-HTT selective radiotracer [¹¹C]DASB in 23 non-diabetic individuals with obesity and 14 healthy, non-obesity controls. Parametric images of binding potential BP_ND were generated from the PET data and analyzed together with HbA1c levels by using volume of interest analysis for brain areas relevant to appetite control. Voxel-based morphometry (VBM) of individual magnetic resonance imaging data was further performed to correlate grey matter density (GMD)

SUBMITTER: Grundmann R 

PROVIDER: S-EPMC7721891 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature