Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy.

ABSTRACT: While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear. Here, we show the prerequisite role of conventional dendritic cells in submandibular lymph nodes (ManLNs) in the effectiveness of SLIT for the treatment of allergic disorders in mice. Deficiency of conventional dendritic cells or CD4⁺Foxp3⁺ regulatory T (T_reg) cells abrogates the protective effect of SLIT against allergic disorders. Furthermore, sublingual antigenic application primarily induces antigen-specific CD4⁺Foxp3⁺ T_reg cells in draining ManLNs, in which it is severely impaired in the absence of cDCs. In ManLNs, migratory CD11b⁺ cDCs are superior to o

SUBMITTER: Miyanaga N 

PROVIDER: S-EPMC7721894 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature