[¹⁸F]-Fluciclovine PET discrimination of recurrent intracranial metastatic disease from radiation necrosis.

ABSTRACT:

Background

Stereotactic radiosurgery (SRS) is often the primary treatment modality for patients with intracranial metastatic disease. Despite advances in magnetic resonance imaging, including use of perfusion and diffusion sequences and molecular imaging, distinguishing radiation necrosis from progressive tumor remains a diagnostic and clinical challenge. We investigated the sensitivity and specificity of ¹⁸F-fluciclovine PET to accurately distinguish radiation necrosis from recurrent intracranial metastatic disease in patients who had previously undergone SRS.

Methods

Fluciclovine PET imaging was performed in 8 patients with a total of 15 lesions that had previously undergone SRS and had subsequent MRI and clinical features suspicious for recurrent disease. The S

SUBMITTER: Parent EE 

PROVIDER: S-EPMC7721921 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature