Impact of the dosimetry approach on the resulting ⁹⁰Y radioembolization planned absorbed doses based on ^99mTc-MAA SPECT-CT: is there agreement between dosimetry methods?

ABSTRACT:

Background

Prior radioembolization, a simulation using ^99mTc-macroaggregated albumin as ⁹⁰Y-microspheres surrogate is performed. Gamma scintigraphy images (planar, SPECT, or SPECT-CT) are acquired to evaluate intrahepatic ⁹⁰Y-microspheres distribution and detect possible extrahepatic and lung shunting. These images may be used for pre-treatment dosimetry evaluation to calculate the ⁹⁰Y activity that would get an optimal tumor response while sparing healthy tissues. Several dosimetry methods are available, but there is still no consensus on the best methodology to calculate absorbed doses. The goal of this study was to retrospectively evaluate the impact of using different dosimetry approaches on the resulting ⁹⁰Y-radioembolizat

SUBMITTER: Moran V 

PROVIDER: S-EPMC7721939 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature