Inefficient visual search strategies in the first-episode schizophrenia spectrum.

ABSTRACT:

Background

Knowledge is lacking regarding deficits in selective attention and their underlying biological mechanisms during early stages of schizophrenia. The present study examined the N2pc, a neurophysiological index of covert spatial attention, and its cortical sources at first psychotic episode in the schizophrenia spectrum (FESz).

Methods

Neurophysiological responses measured simultaneously with magnetoencephalography (MEG) and electroencephalography (EEG) during pop-out and serial search tasks were compared between 32 FESz and 32 matched healthy controls (HC). Mean scalp-recorded N2pc was measured from a cluster of posterior-lateral EEG electrodes. Cortical source-resolved MEG activity contributing to the N2pc signal was derived for the intraparietal sulcus (IPS) and l

SUBMITTER: Sklar AL 

PROVIDER: S-EPMC7722051 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature