Anti-Neutrophil Extracellular Trap Antibodies and Impaired Neutrophil Extracellular Trap Degradation in Antiphospholipid Syndrome.

ABSTRACT:

Objective

The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils has recently been recognized to play an important role in antiphospholipid syndrome (APS). This study was undertaken to evaluate autoantibodies targeting NETs in patients with primary APS, and to determine their potential functions and clinical associations.

Methods

We measured global anti-NET activity in 76 patients with primary APS, 23 patients with systemic lupus erythematosus without antiphospholipid antibodies (aPL), 11 patients with a history of unprovoked venous thrombosis without aPL, and 44 healthy controls. The ability of APS sera to degrade NETs was also assessed.

Results

We found markedly elevated levels of anti-NET IgG and IgM in patients with primary APS compared wi

SUBMITTER: Zuo Y 

PROVIDER: S-EPMC7722115 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature