Simultaneous QSM and metabolic imaging of the brain using SPICE: Further improvements in data acquisition and processing.

ABSTRACT:

Purpose

To achieve high-resolution mapping of brain tissue susceptibility in simultaneous QSM and metabolic imaging.

Methods

Simultaneous QSM and metabolic imaging was first achieved using SPICE (spectroscopic imaging by exploiting spatiospectral correlation), but the QSM maps thus obtained were at relatively low-resolution (2.0 × 3.0 × 3.0 mm³ ). We overcome this limitation using an improved SPICE data acquisition method with the following novel features: 1) sampling (k, t)-space in dual densities, 2) sampling central k-space fully to achieve nominal spatial resolution of 3.0 × 3.0 × 3.0 mm³ for metabolic imaging, and 3) sampling outer k-space sparsely to achieve spatial resolution of 1.0 × 1.0 × 1.9 mm³ for QSM. To keep the scan time short,

SUBMITTER: Guo R 

PROVIDER: S-EPMC7722130 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature