Associations between resting-state functional connectivity and treatment response in a randomized clinical trial for posttraumatic stress disorder.

ABSTRACT:

Background

Alterations in resting-state functional connectivity (rsFC) have been reported in posttraumatic stress disorder (PTSD). Here, we examined pre- and post-treatment rsFC during a randomized clinical trial to characterize alterations and examine predictors of treatment response.

Methods

Sixty-four combat veterans with PTSD were randomly assigned to prolonged exposure (PE) plus placebo, sertraline plus enhanced medication management, or PE plus sertraline. Symptom assessment and resting-state functional magnetic resonance imaging (fMRI) scans occurred before and after treatment. Twenty-nine trauma-exposed combat veterans without PTSD served as a control group at intake. Seed-based and region of interest (ROI)-to-ROI connectivities, as well as an exploratory connectome-

SUBMITTER: Sheynin J 

PROVIDER: S-EPMC7722156 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature